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ANTI INFLAMMATORY ACTIVITY OF SOURSOP

 

Due to significant side effects of steroid and non steroidal Anti-inflammatory Drugs (NSAID), there is an increasing interest in herbal remedies that have been in use for many years to minimize pain and inflammation. The great number of natural compounds work similarly to that of the NSAIDs.

The mechanism of antinociception (reduced sensitivity to pain) has been shown to inhibit cyclooxygenase (COX) and lipoxygenases (LOX) through inflammatory mediators such as flavonoids present in the plant extract.

The anti-inflammatory effects of Annona muricata are thus demonstrated to occur through suppression of inflammatory mediators.

A. muricata produced dose-dependent and significant results, which were comparatively similar to the inhibition of inflammatory pain produced by morphine (96.08%) standard reference drug. The effect of the extract in this phase suggests that it may have an anti-inflammatory property.

In conclusion, findings from the results of the studies showed that A. muricata possesses analgesic and anti-inflammatory activities in various models. The analgesic effect involves interaction with peripheral mechanisms and opioid system, whereas the anti-inflammatory property involves inhibition of COX activity and nitric oxide generation. Hence justify its use in traditional African medicine in the management of painful conditions and inflammatory disorders.

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