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ANTIULCER PROPERTY OF SOURSOP - LAXMANPHAL (Annona muricata)

 



ANTIULCER PROPERTIES OF SOURSOP - LAXMANPHAL (Annona muricata)

Annona muricata contains high concentrations of flavonoids, tannins, and phenolic acid, making it a strong antioxidant, anti-inflammatory, and gastro-protective properties. A survey revealed that the leaves and bark of A. muricata are popularly used to make tea, used in the treatment of gastrointestinal problems such as gastritis, and poor digestion.

In a study carried out by (REF. 1), A. muricata has also been reported to improve gastric lesions. The hydroalcoholic extract of A. muricata leaves to treat ulcers in absolute and acidified methanol or indomethacin-induced lesions in rats showed that the extract reduced the ulceration process by activating prostaglandin synthesis as a gastro-protector and suppressed aggressive factors of the gastric mucosa.

Another study carried out by (REF. 2)  on A. muricata ethyl acetate extract showed antiulcer activity via ROS-scavenging and gastric wall damage protection in rats with ethanol-induced gastric injury.

The minimum inhibitory concentration of A. muricata leaf extract against H. pylori is 20 mg/ml. (REF. 3)

A. muricata also inhibited inflammatory mediators such as 1L-1β, TNF-a, and IL-6 (REF. 4)

 

REFERENCES:

1.  Bento, E.B. et al. Antiulcerogenic Activity of the Hydroalcoholic Extract of Leaves of Annona muricata Linnaeus in Mice. Saudi J. Biol. Sci. 2016, 25, 609–621.

2.  Moghadamtousi, S.Z. et al., Gastroprotective Activity of Annona muricata Leaves against Ethanol-Induced Gastric Injury in Rats via Hsp70/Bax Involvement. Drug Des. Devel. Ther. 2014, 8, 2099–2111.

3.  Ngnameko, C.R. Inhibitory Effect of Medicinal Plants from Cameroon on the Growth and Adhesion of Helicobacter Pylori. Eur. J. Integr. Med.  2019, 30, 100957.

4. Laksmitawati, D.R. et al., Anti-Inflammatory Potential of Gandarusa (Gendarussa Vulgaris Nees) and Soursoup (Annona muricata L.) Extracts in LPS Stimulated-Macrophage Cell (RAW264.7). J. Nat. Remedies 2016, 16, 73–81.

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