ANTIULCER PROPERTIES OF SOURSOP - LAXMANPHAL (Annona muricata)
Annona muricata contains high concentrations of flavonoids,
tannins, and phenolic acid, making it a strong antioxidant, anti-inflammatory,
and gastro-protective properties. A survey revealed that the leaves and bark of
A. muricata are popularly used to
make tea, used in the treatment of gastrointestinal problems such as gastritis,
and poor digestion.
In a study
carried out by (REF. 1), A. muricata has
also been reported to improve gastric lesions. The hydroalcoholic extract of A. muricata leaves to treat ulcers in
absolute and acidified methanol or indomethacin-induced lesions in rats showed
that the extract reduced the ulceration process by activating prostaglandin
synthesis as a gastro-protector and suppressed aggressive factors of the
gastric mucosa.
Another study carried out by (REF. 2) on
A. muricata ethyl acetate extract
showed antiulcer activity via ROS-scavenging and gastric wall damage protection
in rats with ethanol-induced gastric injury.
The minimum inhibitory concentration of A. muricata leaf extract against H. pylori is 20 mg/ml. (REF. 3)
A. muricata
also inhibited inflammatory mediators such as 1L-1β, TNF-a, and IL-6 (REF. 4)
REFERENCES:
1. Bento, E.B. et al. Antiulcerogenic Activity of
the Hydroalcoholic Extract of Leaves of Annona muricata Linnaeus in Mice. Saudi
J. Biol. Sci. 2016, 25, 609–621.
2. Moghadamtousi, S.Z. et al., Gastroprotective
Activity of Annona muricata Leaves against Ethanol-Induced Gastric Injury in
Rats via Hsp70/Bax Involvement. Drug Des. Devel. Ther. 2014, 8, 2099–2111.
3. Ngnameko, C.R. Inhibitory Effect of Medicinal
Plants from Cameroon on the Growth and Adhesion of Helicobacter Pylori. Eur. J.
Integr. Med. 2019, 30, 100957.
4. Laksmitawati,
D.R. et al., Anti-Inflammatory Potential of Gandarusa (Gendarussa Vulgaris
Nees) and Soursoup (Annona muricata L.) Extracts in LPS Stimulated-Macrophage
Cell (RAW264.7). J. Nat. Remedies 2016, 16, 73–81.
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