Annona muricata L. is a tropical tree that is used in traditional medicine around the world. The high content of flavonoid, alkaloid, acetogenin, phenolic, and lipophilic compounds of this tropical tree forms the basis of its traditional medical uses.
According to 49 research
articles studied, the pharmacological properties of Soursop are reported to include
8% antiviral properties.
Ethanolic extracts from the stem and bark of A. muricata showed in vitro antiviral
activity against herpes simplex virus (ref.
Padma, P.; Pramod, N.P.; Thyagarajan, S.P.; Khosa, R.L. Effect of the Extract
of Annona muricata and Petunia Nyctaginiflora on Herpes Simplex Virus. J. Ethnopharmacol.
1998, 61, 81–83.)
Acetogenins
such as annomuricin a, annomuricin b, annomuricin c, muricatocin c,
muricatacin, cis-annonacin, annonacin-10-one, cis-goniothalamicin, arianacin,
and javoricin were shown to possess good inhibitory activity against SARS-CoV-2
spike proteins (in silico). Cis-annonacin had a low binding energy and greater
hydrogen bond formation ability, which indicated that it was the most potent
among the acetogenins tested in the study. This result suggests that
annonaceous acetogenins can be considered as potential anti-SARS-CoV-2 agents
and should be studied in vitro and in vivo (Ref. Prasad, S.K.; Pradeep, S.; Shimavallu, C.; Kollur, S.P.; Syed, A.;
Marraiki, N.; Egbuna, C.; Gaman, M.A.; Kosakowska, O.; Cho, W.C.; et al.
Evaluation of Annona muricata Acetogenins as Potential Anti-SARS-CoV-2 Agents
Through Computational Approaches. Front. Chem. 2021, 8, 1–7.)
Comments
Post a Comment