Skip to main content

SOURSOP IN CANCER ADJUVANT THERAPY

 


Annonaceous Acetogenins are the most valuable phytochemicals present in Soursop/ Laxmanphal, scientifically known as Annona muricata. Annonaceous acetogenins typically are derivatives of long chain fatty acids that are selectively toxic to Cancer cells, including multidrug resistant Cancer cells.

Scientific research carried out by Hadisaputri et al (2021) conclude that Annona muricata leaf extract is responsible for the induction of apoptosis of breast cancer cells. This apoptosis is majorly due to reduction in the integrity of mitochondrial cells.

Cancer cells may develop Multi Drug Resistance (MDR), a phenomenon in which Cancer cells develops resistivity against the the specific drug being used in the Cancer treatment. Acetogenins (ACG) in Soursop are found to be cytotoxic to these Drug Resistant Cancer cells. As a result, these Cancer cells undergo death and decay, preventing the spread of Cancer to other parts of body (Metastasis).

Annonaceous acetogenins induce cytotoxicity, at least in part, by inhibiting mitochondrial complex I, which is involved in oxidative phosphorylation and ATP synthesis. As Cancer cells have a higher demand for ATP than the normal cells, mitochondrial complex I inhibitors therefore have great potential in Cancer therapy.

Comments

Post a Comment

Popular posts from this blog

ANNONACEOUS FRUITS

  Family Annonaceae is rich in fruiting plants. Most popular amongst them are Ram phal, Sita phal, Hanuman phal, and Laxman phal. This blog discusses the comparison between all these fruits. Sita phal Annona squamosa is commonly known as Sita phal. Fruit is generally the size of the tennis ball with an irregular surface all over. The fruit pulp is fleshy and sweet with a grainy texure.    Ram phal Annona reticulata is commonly known as Ram phal. The fruit is little bigger than Sita phal. The outer fuit cover is smooth as compared to Sita phal. Hanuman phal Annona cherimola commonly known as Hanuman phal. This fruit has slightly irregular surface. The fruit is sweet in taste and pleasurable to eat.  Laxman phal Annona muricata is commonly known as Laxman phal or Soursop fruit. As the name muricata suggests, this fruit has soft spine all over the fruit surface. The fruit is sour in taste due to high vitamin C.   
Post a Comment
Read more

NUTRITIONAL PROPERTIES OF SOURSOP

  Soursop is loaded with various Minerals and Vitamins, being the reason why Soursop is most popular with health conscious people as well as those with poor health conditions due to serious disease like Cancer.  Minerals are the earth elements found in the foodstuff and are necessary for body growth and normal body functioning. Magnesium (Mg) helps regulate muscle and nerve function. It is generally regarded as good for muscle and bone health.  It helps to maintain blood sugar levels and stomach health. Calcium (Ca) plays an important role in muscle contraction and nerve functioning. It is important to keep the bones and teeth strong and healthy. Iron (Fe) is the integral part of Haemoglobin, responsible for the conduction of Oxygen. It keeps up the immune system and helps in energy production. Potassium (K) is important in lowering blood pressure and, therefore important in maintaining blood pressure. Vitamins are the group of substances required for norm...
Post a Comment
Read more

DISTRIBUTION OF SOURSOP TREE

  The Soursop is the fruit of the tropical tree which is also termed Graviola, Laxmanphal, kaattu aatha palam, Mullen Chakka, Mullu Seettha, Annona muriata, Graviola, Guyabano. proper origin from Brazil, also found in Sri Lanka as well as the southern part of India. It has an aroma similar to pineapple, the flavor of the fruit has been described as a combination of strawberries and apple, and sour citrus flavor notes, contrasting with an underlying creamy texture reminiscent of coconut or banana. The Soursop fruit contains the rich Vitamin C which helps to cure cancer. Soursop fruit is a sweet fruit, seedy fruit with a pure white flush and coated with a green-yellowy colored skin. People in Africa and South America use the bark, leaves, roots, and fruits of the Graviola tree. They treat infections with viruses or parasites, rheumatism, arthritis, depression, and sickness. We know from research that some Graviola extracts can help to treat these condi...
Post a Comment
Read more