Skip to main content

SOURSOP IN CANCER ADJUVANT THERAPY

 


Annonaceous Acetogenins are the most valuable phytochemicals present in Soursop/ Laxmanphal, scientifically known as Annona muricata. Annonaceous acetogenins typically are derivatives of long chain fatty acids that are selectively toxic to Cancer cells, including multidrug resistant Cancer cells.

Scientific research carried out by Hadisaputri et al (2021) conclude that Annona muricata leaf extract is responsible for the induction of apoptosis of breast cancer cells. This apoptosis is majorly due to reduction in the integrity of mitochondrial cells.

Cancer cells may develop Multi Drug Resistance (MDR), a phenomenon in which Cancer cells develops resistivity against the the specific drug being used in the Cancer treatment. Acetogenins (ACG) in Soursop are found to be cytotoxic to these Drug Resistant Cancer cells. As a result, these Cancer cells undergo death and decay, preventing the spread of Cancer to other parts of body (Metastasis).

Annonaceous acetogenins induce cytotoxicity, at least in part, by inhibiting mitochondrial complex I, which is involved in oxidative phosphorylation and ATP synthesis. As Cancer cells have a higher demand for ATP than the normal cells, mitochondrial complex I inhibitors therefore have great potential in Cancer therapy.

Comments

Post a Comment

Popular posts from this blog

ANTI INFLAMMATORY PROPERTY OF SOURSOP

  Due to significant side effects of steroid and non steroidal Anti-inflammatory Drugs (NSAID), there is an increasing interest in herbal remedies that have been in use for many years to minimize pain and inflammation. The great number of natural compounds work similarly to that of the NSAIDs. The mechanism of antinociception (reduced sensitivity to pain) has been shown to inhibit cyclooxygenase (COX) and lipoxygenases (LOX) through inflammatory mediators such as flavonoids present in the plant extract. The anti-inflammatory effects of Annona muricata are thus demonstrated to occur through suppression of inflammatory mediators. A. muricata produced dose-dependent and significant results, which were comparatively similar to the inhibition of inflammatory pain produced by morphine (96.08%) standard reference drug. The effect of the extract in this phase suggests that it may have an anti-inflammatory property. In conclusion, findings from the results of the studies showed th...
Post a Comment
Read more

ANTIMICROBIAL PROPERT OF SOURSOP

  Soursop is appreciated for its high effectivity to fight against Cancer. Some studies reveal that Soursop contains antimicrobial properties as well. Antimicrobial property Soursop can combat various bacterial and parasitic infections. This effect is largely due to the presence of bioactive compounds like Acetogenins, Flavonoids, and Alkaloids in the Soursop fruit and leaves extract. These compounds destroy the integrity of microbial cell membranes and inhibit essential enzymes there by preventing the growth and proliferation of pathogen. The study indicates the Soursop fruit and leaves extracts are effective in treating infections caused by resistant strains making them a promising alternative to conventional antibiotics. Soursop shows antimicrobial efficacy was evaluated using the disc diffusion method against  Streptococcus mutans ,  Streptococcus mitis ,  Porphyromonas gingivalis ,  Prevotella intermedia , and  Candida albicans in laboratory con...
Post a Comment
Read more

PHARMACOLOGICAL PROPERTIES OF SOURSOP

  Annona muricata L., popularly known as Laxman phal or Graviola, is widely used as a traditional medicine. Plant parts of Soursop, such as fruit, leaves, and bark, have medicinal properties. We have studied 49 research papers, which conclude that the pharmacological properties of Soursop shows Anticancer - 25%, antiulcer - 17%, antidiabetic - 14%, antiprotozoal - 10%, antidiarrhea - 8%, antibacterial - 8%, antiviral 8%, antihypertensive - 6%, wound healing properties - 4%.  The important active compounds in Annona muricata L. are Acetogenin - 49%, Alkaloids -26%, Flavonoids - 19%, and others - 6%, which are reportedly responsible for Soursop's pharmacological properties.   Acetogenins, which are active components, are temperature sensitive. Therefore, it's challenging to scale up and produce stable raw material for commercial production. Thus, developing drug preparations is difficult, despite sufficient evidence of bioactivity of Acetogenins.  To get the...
Post a Comment
Read more