SOURSOP IN CANCER ADJUVANT THERAPY

Annonaceous Acetogenins are the most valuable phytochemicals present in Soursop/ Laxmanphal, scientifically known as Annona muricata. Annonaceous acetogenins typically are derivatives of long chain fatty acids that are selectively toxic to Cancer cells, including multidrug resistant Cancer cells.

Scientific research carried out by Hadisaputri et al (2021) conclude that Annona muricata leaf extract is responsible for the induction of apoptosis of breast cancer cells. This apoptosis is majorly due to reduction in the integrity of mitochondrial cells.

Cancer cells may develop Multi Drug Resistance (MDR), a phenomenon in which Cancer cells develops resistivity against the the specific drug being used in the Cancer treatment. Acetogenins (ACG) in Soursop are found to be cytotoxic to these Drug Resistant Cancer cells. As a result, these Cancer cells undergo death and decay, preventing the spread of Cancer to other parts of body (Metastasis).

Annonaceous acetogenins induce cytotoxicity, at least in part, by inhibiting mitochondrial complex I, which is involved in oxidative phosphorylation and ATP synthesis. As Cancer cells have a higher demand for ATP than the normal cells, mitochondrial complex I inhibitors therefore have great potential in Cancer therapy.

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ANNONACEOUS FRUITS

Family Annonaceae is rich in fruiting plants. Most popular amongst them are Ram phal, Sita phal, Hanuman phal, and Laxman phal. This blog discusses the comparison between all these fruits. Sita phal Annona squamosa is commonly known as Sita phal. Fruit is generally the size of the tennis ball with an irregular surface all over. The fruit pulp is fleshy and sweet with a grainy texure. Ram phal Annona reticulata is commonly known as Ram phal. The fruit is little bigger than Sita phal. The outer fuit cover is smooth as compared to Sita phal. Hanuman phal Annona cherimola commonly known as Hanuman phal. This fruit has slightly irregular surface. The fruit is sweet in taste and pleasurable to eat. Laxman phal Annona muricata is commonly known as Laxman phal or Soursop fruit. As the name muricata suggests, this fruit has soft spine all over the fruit surface. The fruit is sour in taste due to high vitamin C.

NUTRITIONAL PROPERTIES OF SOURSOP

Soursop is loaded with various Minerals and Vitamins, being the reason why Soursop is most popular with health conscious people as well as those with poor health conditions due to serious disease like Cancer. Minerals are the earth elements found in the foodstuff and are necessary for body growth and normal body functioning. Magnesium (Mg) helps regulate muscle and nerve function. It is generally regarded as good for muscle and bone health. It helps to maintain blood sugar levels and stomach health. Calcium (Ca) plays an important role in muscle contraction and nerve functioning. It is important to keep the bones and teeth strong and healthy. Iron (Fe) is the integral part of Haemoglobin, responsible for the conduction of Oxygen. It keeps up the immune system and helps in energy production. Potassium (K) is important in lowering blood pressure and, therefore important in maintaining blood pressure. Vitamins are the group of substances required for norm...

SOURSOP TREE GROWTH PROGRESS

On favorable conditions, the Soursop seeds germinate after about 45 days. Successful germination enables further growth of the sapling which may reach to 1-2 feet after about one year. These small saplings are protected from the external physical damage and allowed to grow. Soursop plant attains about 3-6 feet within a span of about 2 years. With abundant sunlight and proper care with fertilizers and minimal pesticides, Soursop tree grows upto 7-10 feet and mature enough to get the flowering. These flowers on successful pollination grows into fruit. Soursop tree can bear upto 12-15 kg of fruits after 3-4 years of growth. With the help of proper fertilizers, after 5 years of growth, Soursop can bear upto 30-35 kg per tree in a single season. Intercrops like Onion, Tomato, Chilly or any other herb plant can be grown simultaneously to increase the gains. The fertilizers applied to intercrops are also shared with the Soursop tree, helping Soursop trees to grow more vigorously

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