Skip to main content

PHARMACOLOGICAL PROPERTIES OF SOURSOP

 Annona muricata L., popularly known as Laxman phal or Graviola, is widely used as a traditional medicine. Plant parts of Soursop, such as fruit, leaves, and bark, have medicinal properties. We have studied 49 research papers, which conclude that the pharmacological properties of Soursop shows Anticancer - 25%, antiulcer - 17%, antidiabetic - 14%, antiprotozoal - 10%, antidiarrhea - 8%, antibacterial - 8%, antiviral 8%, antihypertensive - 6%, wound healing properties - 4%. 

The important active compounds in Annona muricata L. are Acetogenin - 49%, Alkaloids -26%, Flavonoids - 19%, and others - 6%, which are reportedly responsible for Soursop's pharmacological properties.  

Acetogenins, which are active components, are temperature sensitive. Therefore, it's challenging to scale up and produce stable raw material for commercial production. Thus, developing drug preparations is difficult, despite sufficient evidence of bioactivity of Acetogenins. 

To get the pharmacological benefits of the Soursop, using it in its natural form is the better option. Soursop natural products that are made from Soursop pulp and Soursop leaves are popular and most beneficial for boosting immunity and tackling chronic diseases, including Cancer. 




Comments

Popular posts from this blog

ANTIVIRAL PROPERTY OF SOURSOP

  A nnona muricata  L. is a tropical tree that is used in traditional medicine around the world. The high content of flavonoid, alkaloid, acetogenin, phenolic, and lipophilic compounds of this tropical tree forms the basis of its traditional medical uses. According to 49 research articles studied, the pharmacological properties of Soursop are reported to include 8% antiviral properties. Ethanolic extracts from the stem and bark of  A. muricata  showed in vitro antiviral activity against herpes simplex virus (ref. Padma, P.; Pramod, N.P.; Thyagarajan, S.P.; Khosa, R.L. Effect of the Extract of Annona muricata and Petunia Nyctaginiflora on Herpes Simplex Virus. J. Ethnopharmacol. 1998, 61, 81–83.) Acetogenins such as annomuricin a, annomuricin b, annomuricin c, muricatocin c, muricatacin, cis-annonacin, annonacin-10-one, cis-goniothalamicin, arianacin, and javoricin were shown to possess good inhibitory activity against SARS-CoV-2 spike proteins (in silico). Cis-a...

ANTI INFLAMMATORY PROPERTY OF SOURSOP

  Due to significant side effects of steroid and non steroidal Anti-inflammatory Drugs (NSAID), there is an increasing interest in herbal remedies that have been in use for many years to minimize pain and inflammation. The great number of natural compounds work similarly to that of the NSAIDs. The mechanism of antinociception (reduced sensitivity to pain) has been shown to inhibit cyclooxygenase (COX) and lipoxygenases (LOX) through inflammatory mediators such as flavonoids present in the plant extract. The anti-inflammatory effects of Annona muricata are thus demonstrated to occur through suppression of inflammatory mediators. A. muricata produced dose-dependent and significant results, which were comparatively similar to the inhibition of inflammatory pain produced by morphine (96.08%) standard reference drug. The effect of the extract in this phase suggests that it may have an anti-inflammatory property. In conclusion, findings from the results of the studies showed th...

ANTI HYPERTENSIVE ACTIVITY OF SOURSOP

  Annona muricata  L. is a tropical tree that is used in traditional medicine around the world. The high content of flavonoid, alkaloid, acetogenin, phenolic, and lipophilic compounds of this tropical tree forms the basis of its traditional medical uses. According to 49 research articles studied, the pharmacological properties of Soursop are reported to include 6% antihypertensive properties. In a study carried out in Jamaica, it was found that Annona muricata shows antioxidant and antihypertensive properties through Angiotensin-I-converting enzymes in vitro. The suggested hypotensive mechanism of A. muricata takes action through the blockage of calcium ion channels, that lowers the blood pressure. The hypotensive effects of A. muricata are not mediated through muscarinic, histaminergic, adrenergic, and nitric oxide pathways, but through peripheral mechanisms involving antagonism of Ca(2+). (REF.  Nwokocha, C.R.; Owu, D.U.; Gordon, A.; Thaxter, K.; Mccalla, G.; Ozo...