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ANTI HYPERTENSIVE ACTIVITY OF SOURSOP

 


Annona muricata L. is a tropical tree that is used in traditional medicine around the world. The high content of flavonoid, alkaloid, acetogenin, phenolic, and lipophilic compounds of this tropical tree forms the basis of its traditional medical uses.

According to 49 research articles studied, the pharmacological properties of Soursop are reported to include 6% antihypertensive properties.

In a study carried out in Jamaica, it was found that Annona muricata shows antioxidant and antihypertensive properties through Angiotensin-I-converting enzymes in vitro. The suggested hypotensive mechanism of A. muricata takes action through the blockage of calcium ion channels, that lowers the blood pressure. The hypotensive effects of A. muricata are not mediated through muscarinic, histaminergic, adrenergic, and nitric oxide pathways, but through peripheral mechanisms involving antagonism of Ca(2+). (REF.  Nwokocha, C.R.; Owu, D.U.; Gordon, A.; Thaxter, K.; Mccalla, G.; Ozolua, R.I.; Young, L. Possible Mechanisms of Action of the Hypotensive Effect of Annona muricata (Soursop) in Normotensive Sprague Dawley Rats. Pharm. Biol. 2012, 50, 1436–1441.)

 

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