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ANTIPROTOZOAL ACTIVITY OF SOURSOP

SOURSOP SHOWS ANTIPROTOZOAL ACTIVITY


Trypanosomiasis, Leishmaniasis, Toxoplasmosis, and Malaria are the most common protozoal diseases worldwide. Therapies developed using medicinal plants have gained importance due to the lack of treatment options for parasitic protozoal infections.

The following studies were conducted to investigate the antiprotozoal activity of Annona muricata.  
* A. muricata ethanol leaf extract showed antiprotozoal activity against Toxoplasma gondii. Reference A
* A. muricata ethyl acetate leaf extract showed antiprotozoal activity against Leishmania spp. and Trypanosoma cruzii. Reference B
* A. muricata ethanol leaf extract also has antiprotozoal activity against Plasmodium falciparum. Additionally, the dichloromethane fractions and subfractions of A. muricata bark and roots showed antiprotozoal activity against P. falciparum. Reference A
* Gallic acid compounds isolated from the bark and roots of A. muricata showed activity against P. falciparum. Reference C

 Ref. A Leesombun, A.; Boonmasawai, S.; Nishikawa, Y. Ethanol Extracts from Thai Plants Have Anti-Plasmodium and Anti-Toxoplasma Activities In Vitro. Acta Parasitol. 2019, 64, 257–261.

Ref. B  Osorio, E.; Arango, G.J.; Jiménez, N.; Alzate, F.; Ruiz, G.; Gutiérrez, D.; Paco, M.A.; Giménez, A.; Robledo, S. Antiprotozoal and Cytotoxic Activities in Vitro of Colombian Annonaceae. J. Ethnopharmacol. 2007, 111, 630–635.

Ref. C Yamthe, L.; Fokou, P.; Mbouna, C.; Keumoe, R.; Ndjakou, B.; Djouonzo, P.; Mfopa, A.; Legac, J.; Tsabang, N.; Gut, J.; et al. Extracts from Annona muricata L. and Annona reticulata L. (Annonaceae) Potently and Selectively Inhibit Plasmodium Falciparum. Medicines 2015, 2, 55–66.

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