Soursop Information Blog for Awareness

  Annona muricata  L. is a tropical tree that is used in traditional medicine around the world. The high content of flavonoid, alkaloid, acetogenin, phenolic, and lipophilic compounds of this tropical tree forms the basis of its traditional medical uses. According to 49 research articles studied, the pharmacological properties of Soursop are reported to include 6% antihypertensive properties. In a study carried out in Jamaica, it was found that Annona muricata shows antioxidant and antihypertensive properties through Angiotensin-I-converting enzymes in vitro. The suggested hypotensive mechanism of A. muricata takes action through the blockage of calcium ion channels, that lowers the blood pressure. The hypotensive effects of A. muricata are not mediated through muscarinic, histaminergic, adrenergic, and nitric oxide pathways, but through peripheral mechanisms involving antagonism of Ca(2+). (REF.  Nwokocha, C.R.; Owu, D.U.; Gordon, A.; Thaxter, K.; Mccalla, G.; Ozo...

  A nnona muricata  L. is a tropical tree that is used in traditional medicine around the world. The high content of flavonoid, alkaloid, acetogenin, phenolic, and lipophilic compounds of this tropical tree forms the basis of its traditional medical uses. According to 49 research articles studied, the pharmacological properties of Soursop are reported to include 8% antiviral properties. Ethanolic extracts from the stem and bark of  A. muricata  showed in vitro antiviral activity against herpes simplex virus (ref. Padma, P.; Pramod, N.P.; Thyagarajan, S.P.; Khosa, R.L. Effect of the Extract of Annona muricata and Petunia Nyctaginiflora on Herpes Simplex Virus. J. Ethnopharmacol. 1998, 61, 81–83.) Acetogenins such as annomuricin a, annomuricin b, annomuricin c, muricatocin c, muricatacin, cis-annonacin, annonacin-10-one, cis-goniothalamicin, arianacin, and javoricin were shown to possess good inhibitory activity against SARS-CoV-2 spike proteins (in silico). Cis-a...

  ANTIULCER PROPERTIES OF SOURSOP - LAXMANPHAL ( Annona muricata ) Annona muricata contains high concentrations of flavonoids, tannins, and phenolic acid, making it a strong antioxidant, anti-inflammatory, and gastro-protective properties. A survey revealed that the leaves and bark of A. muricata are popularly used to make tea, used in the treatment of gastrointestinal problems such as gastritis, and poor digestion. In a study carried out by (REF. 1), A. muricata has also been reported to improve gastric lesions. The hydroalcoholic extract of A. muricata leaves to treat ulcers in absolute and acidified methanol or indomethacin-induced lesions in rats showed that the extract reduced the ulceration process by activating prostaglandin synthesis as a gastro-protector and suppressed aggressive factors of the gastric mucosa. Another study carried out by (REF. 2)   on A. muricata ethyl acetate extract showed antiulcer activity via ROS-scavenging and gastric wall damage pro...

  Due to significant side effects of steroid and non steroidal Anti-inflammatory Drugs (NSAID), there is an increasing interest in herbal remedies that have been in use for many years to minimize pain and inflammation. The great number of natural compounds work similarly to that of the NSAIDs. The mechanism of antinociception (reduced sensitivity to pain) has been shown to inhibit cyclooxygenase (COX) and lipoxygenases (LOX) through inflammatory mediators such as flavonoids present in the plant extract. The anti-inflammatory effects of Annona muricata are thus demonstrated to occur through suppression of inflammatory mediators. A. muricata produced dose-dependent and significant results, which were comparatively similar to the inhibition of inflammatory pain produced by morphine (96.08%) standard reference drug. The effect of the extract in this phase suggests that it may have an anti-inflammatory property. In conclusion, findings from the results of the studies showed th...

  Annona muricata L., popularly known as Laxman phal or Graviola, is widely used as a traditional medicine. Plant parts of Soursop, such as fruit, leaves, and bark, have medicinal properties. We have studied 49 research papers, which conclude that the pharmacological properties of Soursop shows Anticancer - 25%, antiulcer - 17%, antidiabetic - 14%, antiprotozoal - 10%, antidiarrhea - 8%, antibacterial - 8%, antiviral 8%, antihypertensive - 6%, wound healing properties - 4%.  The important active compounds in Annona muricata L. are Acetogenin - 49%, Alkaloids -26%, Flavonoids - 19%, and others - 6%, which are reportedly responsible for Soursop's pharmacological properties.   Acetogenins, which are active components, are temperature sensitive. Therefore, it's challenging to scale up and produce stable raw material for commercial production. Thus, developing drug preparations is difficult, despite sufficient evidence of bioactivity of Acetogenins.  To get the...

    LAXMANPHAL - SOURSOP - Annona muricata exhibits Antidiabetic activity. A. muricata fruit extracts were reported to have excellent antioxidant and antidiabetic properties by inhibiting key enzymes relevant to type 2 diabetes mellitus, such as α-amylase and α-glucosidase, in vitro. It contains Flavonoids that inhibit α-glucosidase activity through hydroxylation bonding that suppresses carbohydrate hydrolysis and glucose absorption and inhibits carbohydrate metabolism into glucose. The fruit pulp and leaf extract shows high effectiveness in inhibiting α-amylase and α-glucosidase, which minimizes the rate of glucose assimilation into the bloodstream after feeding, as compared with the standard drug. (Agu, K.C.; Eluehike et al., Inhibition of α-Amylase and α-Glucosidase Activities. Clin. Phytosci., 5, 1–13, 2019)