Soursop Information Blog for Awareness

A NORMAL APOPTOSIS PROCESS APOPTOSIS Apoptosis is a Greek word, meaning to drop off. This term is more relevantly used at the cellular level as the 'cell death' on receiving a certain stimulus. Apoptosis is an important phenomenon that plays an important role in the pathogenesis of many diseases. Low or high rates of Apoptosis are culprits in some degenerative diseases. Cancer is a cellular condition where the rate of Apoptosis is less, resulting in malignant cells that will not die, giving rise to a lump of cells, termed Cancer. In Cancer treatment, targeting Apoptosis in Cancer cells is an important aspect. Defective Apoptotic pathways play a crucial role in Carcinogenesis and can be tackled with targeted Apoptosis with the help of some nutraceutical products. Soursop fruits are rich in Acetogenins, which are known to be selectively toxic to Cancer cells.

  Annonaceous Acetogenins are the most valuable phytochemicals present in Soursop/ Laxmanphal, scientifically known as Annona muricata . Annonaceous acetogenins typically are derivatives of long chain fatty acids that are selectively toxic to Cancer cells, including multidrug resistant Cancer cells. Scientific research carried out by Hadisaputri et al (2021) conclude that Annona muricata leaf extract is responsible for the induction of apoptosis of breast cancer cells. This apoptosis is majorly due to reduction in the integrity of mitochondrial cells. Cancer cells may develop Multi Drug Resistance (MDR), a phenomenon in which Cancer cells develops resistivity against the the specific drug being used in the Cancer treatment. Acetogenins (ACG) in Soursop are found to be cytotoxic to these Drug Resistant Cancer cells. As a result, these Cancer cells undergo death and decay, preventing the spread of Cancer to other parts of body (Metastasis). Annonaceous acetogenins induce cy...

  The phytochemistry of  Annona muricata  L. (Laxmanphal) There are sufficient reasons that Soursop is gaining its popularity in the Health Sector. Soursop is rich in various phytochemicals, Vitamins and minerals that are proved to be helpful in eliminating bad cells. It provide vigour and vitality to the body, helping immune system to deal with the chronic diaseases including Cancer. Inflammation is also prerequisite for the developemnt of various Cancers. Soursop is known to inhibit the cell proliferation and to decrease the tumor growth. Anti-inflammatory effect is also a beneficial and effective strategy in the management of solid Cancers through inhibiting the site of inflammation.   Annona muricata shows medicinal properties which include anticancer (25%), antiulcer (17%), antidiabetic (14%), antiprotozoal (10%), antidiarrhea (8%), antibacterial (8%), antiviral (8%), antihypertensive (6%), and wound healing (4%).  Annona muricata (Laxman phal) frui...

Oxidative Stress Condition  is the tug of war between oxidation-causing agents and antioxidants for electrons . This is a condition when there is an imbalance between the amount of  Reactive Oxygen Species (ROS)  and  Antioxidants . Increasing scientific evidence are concerning, as it suggests that ROS and Oxidative Stress play crucial roles in developing chronic diseases like pathogenesis, such as Cancer, neurodegenerative diseases, and cardiovascular and metabolic diseases.  The body deals with Oxidation causing Factors by producing  Endogenous Enzymatic Antioxidants  such as Superoxide dismutase, catalase, glutathione peroxidase, and non enzymatic antioxidants to stabilize Free Radicals and prevent Oxidative Damage.    Alternatively,  Exogenous Antioxidants  can be obtained from dietary sources. Metabolic compounds found in plants like,  Polyphenols and Flavonoids play an important role in scavenging free radicals b...

  WHAT IS CANCER ? Cancer is a disease in which some of the body’s cells grow uncontrollably and spread to other parts of the body.  The human body is made up of trillions of cells. Cancer can start almost anywhere in the human body. Normally, human cells grow and multiply through a process called cell division. The body's growth demands new cells to be formed. When new cells grow old or become damaged, they die, and new cells take their place. This is the normal growth order in the human body. Sometimes this orderly process breaks down, and abnormal or damaged cells grow and multiply when they should not. These cells may form tumors, which are lumps of tissue. Tumors can be cancerous or not cancerous ( Benign Tumors )  Cancerous tumors spread into, or invade, nearby tissues and can travel to distant places in the body to form new tumors (a process called Metastasis). These spreading Cancerous tumors may also be called Malignant tumors . Many cancers f...

  On favorable conditions, the Soursop seeds germinate after about 45 days. Successful germination enables further growth of the sapling which may reach to 1-2 feet after about one year. These small saplings are protected from the external physical damage and allowed to grow. Soursop plant attains about 3-6 feet within a span of about 2 years. With abundant sunlight and proper care with fertilizers and minimal pesticides, Soursop tree grows upto 7-10 feet and mature enough to get the flowering. These flowers on successful pollination grows into fruit. Soursop tree can bear upto 12-15 kg of fruits after 3-4 years of growth. With the help of proper fertilizers, after 5 years of growth, Soursop can bear upto 30-35 kg per tree in a single season. Intercrops like Onion, Tomato, Chilly or any other herb plant can be grown simultaneously to increase the gains. The fertilizers applied to intercrops are also shared with the Soursop tree, helping Soursop trees to grow more vigorously