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ANTI INFLAMMATORY ACTIVITY OF SOURSOP

  Due to significant side effects of steroid and non steroidal Anti-inflammatory Drugs (NSAID), there is an increasing interest in herbal remedies that have been in use for many years to minimize pain and inflammation. The great number of natural compounds work similarly to that of the NSAIDs. The mechanism of antinociception (reduced sensitivity to pain) has been shown to inhibit cyclooxygenase (COX) and lipoxygenases (LOX) through inflammatory mediators such as flavonoids present in the plant extract. The anti-inflammatory effects of Annona muricata are thus demonstrated to occur through suppression of inflammatory mediators. A. muricata produced dose-dependent and significant results, which were comparatively similar to the inhibition of inflammatory pain produced by morphine (96.08%) standard reference drug. The effect of the extract in this phase suggests that it may have an anti-inflammatory property. In conclusion, findings from the results of the studies showed th...
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PHARMACOLOGICAL PROPERTIES OF SOURSOP

  Annona muricata L., popularly known as Laxman phal or Graviola, is widely used as a traditional medicine. Plant parts of Soursop, such as fruit, leaves, and bark, have medicinal properties. We have studied 49 research papers, which conclude that the pharmacological properties of Soursop shows Anticancer - 25%, antiulcer - 17%, antidiabetic - 14%, antiprotozoal - 10%, antidiarrhea - 8%, antibacterial - 8%, antiviral 8%, antihypertensive - 6%, wound healing properties - 4%.  The important active compounds in Annona muricata L. are Acetogenin - 49%, Alkaloids -26%, Flavonoids - 19%, and others - 6%, which are reportedly responsible for Soursop's pharmacological properties.   Acetogenins, which are active components, are temperature sensitive. Therefore, it's challenging to scale up and produce stable raw material for commercial production. Thus, developing drug preparations is difficult, despite sufficient evidence of bioactivity of Acetogenins.  To get the...
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ANTIDIABETIC EFFECT OF SOURSOP

    LAXMANPHAL - SOURSOP - Annona muricata exhibits Antidiabetic activity. A. muricata fruit extracts were reported to have excellent antioxidant and antidiabetic properties by inhibiting key enzymes relevant to type 2 diabetes mellitus, such as α-amylase and α-glucosidase, in vitro. It contains Flavonoids that inhibit α-glucosidase activity through hydroxylation bonding that suppresses carbohydrate hydrolysis and glucose absorption and inhibits carbohydrate metabolism into glucose. The fruit pulp and leaf extract shows high effectiveness in inhibiting α-amylase and α-glucosidase, which minimizes the rate of glucose assimilation into the bloodstream after feeding, as compared with the standard drug. (Agu, K.C.; Eluehike et al., Inhibition of α-Amylase and α-Glucosidase Activities. Clin. Phytosci., 5, 1–13, 2019)
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ANTIMICROBIAL ACTIVITY OF SOURSOP

  Soursop is appreciated for its high effectivity to fight against Cancer. Some studies reveal that Soursop contains antimicrobial properties as well. Antimicrobial property Soursop can combat various bacterial and parasitic infections. This effect is largely due to the presence of bioactive compounds like Acetogenins, Flavonoids, and Alkaloids in the Soursop fruit and leaves extract. These compounds destroy the integrity of microbial cell membranes and inhibit essential enzymes there by preventing the growth and proliferation of pathogen. The study indicates the Soursop fruit and leaves extracts are effective in treating infections caused by resistant strains making them a promising alternative to conventional antibiotics. Soursop shows antimicrobial efficacy was evaluated using the disc diffusion method against  Streptococcus mutans ,  Streptococcus mitis ,  Porphyromonas gingivalis ,  Prevotella intermedia , and  Candida albicans in laboratory con...
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DEFECTIVE APOPTOSIS - A CANCER CELLS DEVELOPING PROCESS

A NORMAL APOPTOSIS PROCESS APOPTOSIS Apoptosis is a Greek word, meaning to drop off. This term is more relevantly used at the cellular level as the 'cell death' on receiving a certain stimulus. Apoptosis is an important phenomenon that plays an important role in the pathogenesis of many diseases. Low or high rates of Apoptosis are culprits in some degenerative diseases. Cancer is a cellular condition where the rate of Apoptosis is less, resulting in malignant cells that will not die, giving rise to a lump of cells, termed Cancer. In Cancer treatment, targeting Apoptosis in Cancer cells is an important aspect. Defective Apoptotic pathways play a crucial role in Carcinogenesis and can be tackled with targeted Apoptosis with the help of some nutraceutical products. Soursop fruits are rich in Acetogenins, which are known to be selectively toxic to Cancer cells.
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SOURSOP IN CANCER ADJUVANT THERAPY

  Annonaceous Acetogenins are the most valuable phytochemicals present in Soursop/ Laxmanphal, scientifically known as Annona muricata . Annonaceous acetogenins typically are derivatives of long chain fatty acids that are selectively toxic to Cancer cells, including multidrug resistant Cancer cells. Scientific research carried out by Hadisaputri et al (2021) conclude that Annona muricata leaf extract is responsible for the induction of apoptosis of breast cancer cells. This apoptosis is majorly due to reduction in the integrity of mitochondrial cells. Cancer cells may develop Multi Drug Resistance (MDR), a phenomenon in which Cancer cells develops resistivity against the the specific drug being used in the Cancer treatment. Acetogenins (ACG) in Soursop are found to be cytotoxic to these Drug Resistant Cancer cells. As a result, these Cancer cells undergo death and decay, preventing the spread of Cancer to other parts of body (Metastasis). Annonaceous acetogenins induce cy...
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PHYTOCHEMISTRY OF SOURSOP AND ITS MEDICINAL USES

  The phytochemistry of  Annona muricata  L. (Laxmanphal) There are sufficient reasons that Soursop is gaining its popularity in the Health Sector. Soursop is rich in various phytochemicals, Vitamins and minerals that are proved to be helpful in eliminating bad cells. It provide vigour and vitality to the body, helping immune system to deal with the chronic diaseases including Cancer. Inflammation is also prerequisite for the developemnt of various Cancers. Soursop is known to inhibit the cell proliferation and to decrease the tumor growth. Anti-inflammatory effect is also a beneficial and effective strategy in the management of solid Cancers through inhibiting the site of inflammation.   Annona muricata shows medicinal properties which include anticancer (25%), antiulcer (17%), antidiabetic (14%), antiprotozoal (10%), antidiarrhea (8%), antibacterial (8%), antiviral (8%), antihypertensive (6%), and wound healing (4%).  Annona muricata (Laxman phal) frui...
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